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Clinical and Biological Insight into MAPK Signaling and Tumor Heterogeneity Using Circulating Tumor Biomarkers

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Technical Report,01 Sep 2017,31 Aug 2018

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University of California Los Angeles United States

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Prostate cancer is a leading cause of cancer-related mortality in men. Although therapies that inhibit androgen receptor AR activity are initially effective, patients ultimately succumb to metastatic castration resistant prostate cancer mCRPC. The molecular events leading to this are incompletely understood. There is a need for minimally invasive means to obtain tumor information to overcome these knowledge gaps. Circulating tumor cells CTCs are cells that break away from either the primary tumor or metastatic sites. Moreover, serial CTC analyses performed in the context of treatment changes can characterize the mutational landscape of tumors as they evolve, particularly for novel agents such as MEK inhibitors. However, the profiles of sensitivity or resistance to MEK inhibition are unknown, particularly as the tumor may evolve in response to treatment. We have begun to obtain blood samples from patients on a trial of MEK inhibition in prostate cancer to identify molecular predictors of sensitivityresistance. These studies will also help us better understand the molecular basis of sensitivity or resistance to MEK inhibitors, which will help to provide new scientific insights into the pathogenesis of advanced prostate cancer and provide ideas of novel approaches that can be used to treat such tumors.

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  • Medicine and Medical Research

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