Accession Number:

AD1069464

Title:

Entropy Gives Rise to Topologically Associating Domains

Descriptive Note:

Journal Article - Open Access

Corporate Author:

University of South Carolina Columbia United States

Personal Author(s):

• Vasquez, Paula A.
• Hult,Caitlin
• Adalsteinsson,David
• Lawrimore,Josh
• Forest,Mark G.
• Bloom,Kerry

Report Date:

2016-06-02

Pagination or Media Count:

10.0

Abstract:

We investigate chromosome organization within the nucleus using polymer models whose formulation is closely guided by experiments in live yeast cells. We employ bead-spring chromosome models together with loop formation within the chains and the presence of nuclear bodies to quantify the extent to which these mechanisms shape the topological land scape in the interphase nucleus. By investigating the genome as a dynamical system, we show that domains of high chromosomal interactions can arise solely from the polymeric nature of the chromosome arms due to entropic interactions and nuclear confinement. In this view, the role of bio-chemical related processes is to modulate and extend the duration of the interacting domains.

Descriptors:

• chromosome structures
• Entropy
• cell nucleus
• models
• genome
• interactions
• deoxyribonucleic acids
• BEADS

Subject Categories:

• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE