In Vivo Evaluation of OxiClean(trademark) as a Skin Decontamination Material following Topical Application of VX in Guinea Pigs
Technical Report,01 Jan 2018,30 Mar 2018
US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground United States
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OxiCleantrademark is the brand name of a group of commonly used household products marketed for removal of stains from clothing and surfaces. Preliminary in vitro studies in a reaction vessel with one of the products, OxiClean Versatile Stain Remover OVSR, showed a rapid, concentration-dependent destruction of VX and sulfur mustard. These results and the ready availability and low cost of OVSR suggested that this product might be useful for mass casualty skin decontamination DC following exposure to hazardous chemicals. The purpose of this investigation was to evaluate the in vivo effectiveness of OVSR as a skin DC material compared to water and soapy water following topical application of VX. Unanesthetized male guinea pigs were used as subjects. DC was performed 2 min after agent application with 1 or 14 solution wv of OVSR, with a 1 solution vv of Dawn dish detergent or with filtered tap water. DC was performed using a 3-step process. The VX LD50 estimates for water and Dawn detergent DC were 23- to 26-fold higher than the historic untreated LD50 of VX, respectively, while the LD50s for OVSR were shifted only by a maximum of 11-fold. The results suggest that OVSR should not be used for DC of skin exposed to hazardous chemicals.
- Chemical, Biological and Radiological Warfare