Establish and Characterize an Oral Opioid Self-Administration Model
AIR FORCE MEDICAL WING (59TH) Science and Technology LACKLAND AFB United States
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Non-medical opioid use has reached epidemic proportion in the United States. Due to the nature of the work, many service members may be vulnerable to developing opioid use problems. Animal models have already provided valuable information about the reinforcing effects of opioids however improving animal models to better reflect aspects present in human use and could help us better understand, prevent, and treat this problem. Thus, we developed an animal model of opioid use that has better face validity oral rather than intravenous opioid delivery, as is found in many cases of non-medical prescription opioid abuse and incorporates alternative reinforcement, which is ever present and likely important in mitigating opioid abuse in humans, but which is rarely incorporated in to animal models.
- Medicine and Medical Research