Accession Number:

AD1069134

Title:

Detection of Immunoglobulin E with a Graphene-Based Field-Effect Transistor Aptasensor

Descriptive Note:

Journal Article - Open Access

Corporate Author:

University of Illinois Chicago United States

Report Date:

2018-07-22

Pagination or Media Count:

9.0

Abstract:

DNA aptamers have the ability to bind to target molecules with high selectivity and therefore have a wide range of clinical applications. Herein, a graphene substrate functionalized with a DNA aptamer is used to sense immunoglobulin E. The graphene serves as the conductive substrate in this field-effect-transistor-like FET-like structure. A voltage probe in an electrolyte is used to sense the presence of IgE as a result of the changes in the charge distribution that occur when an IgE molecule binds to the IgE DNA-based aptamer. Because IgE is an antibody associated with allergic reactions and immune deficiency-related diseases, its detection is of utmost importance for biomedical applications.

Subject Categories:

  • Electrical and Electronic Equipment
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE