Hierarchical Self Assembly of Multifunctional Biointeractive Surfaces
Technical Report,20 Jul 2012,30 Jun 2016
Stevens Institute of Technology Hoboken United States
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Major Goals The central goal of this research project is to understand the fundamental materials science underlying the design and development of triggered drug-delivery systems that can prevent infection associated with tissue-contacting biomedical devices. This is important to the Army and other DoD agencies, because the treatment of traumatic battlefield injury is often unavoidably compromised by device-associated infection. Such complications can lead to long recovery periods, multiple surgeries, reduced limb function, amputation, or even death. Materials that can avoid device-associated infection will thus substantially enhance the recovery of injured soldiers. The strategic goal of this project is thus to develop materials using a family of multifunctional polymeric microgels with which to control the physico-chemical surface properties of tissue-contacting biomedical devices and enhance their infection resistance while preserving their ability to promote healing. The projects specific objectives center on controlling the self-assembly and complexation phenomena associated with antimicrobial loading into, sequestration within, and triggered release from anionic microgels. We are synthesizing microgels by suspension copolymerization of different acrylate-based monomers, each bringing control over microgel charge, hydrophobicity, and functionality characterizing the average microgel properties using zeta potential measurements and dynamic light scattering DLS quantifying individual microgel properties using various microscopies including cryo-electron microscopy and wet-cell AFM and Assessing bacteriamaterial interactions using gram positivenegative species implicated in biomaterials-associated infections and assessing cell-material interactions using in vitro osteoblast monoculture experiments.
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