Accession Number:

AD1067469

Title:

In Vitro Dermal Absorption Proficiency Demonstration

Descriptive Note:

Technical Report,01 May 2018,31 May 2018

Corporate Author:

Army Public Health Center Aberdeen Proving Ground United States

Personal Author(s):

Report Date:

2019-02-08

Pagination or Media Count:

45.0

Abstract:

The dermal absorption of the three reference substances, benzoic acid, caffeine, and testosterone, was tested as a demonstration of technical proficiency. Reference substances were tested under infinite-dose conditions using the EpiDermTM EPI-606-X RHE model and results compared to published validation studies. Permeation rates were in good general agreement with the results reported in the validation study. The performing lab is therefore technically proficient in performing the in vitro dermal absorption assay and may routinely use this assay for in vitro prediction of skin absorption.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE