Accession Number:



Fourth Generation Agents: Reference Guide

Descriptive Note:

[Technical Report, Other]

Corporate Author:


Personal Author(s):

Report Date:


Pagination or Media Count:



This guide was developed as part of ongoing preparedness for all hazards and is intended to inform decisions, protect emergency responders, and support response operations if an incident ever occurs involving a fourth generation agent FGA, also known as A-series or Novichok nerve agents, such as the one used in the United Kingdom in 2018. No illicit use or manufacture of an FGA or other nerve agent is known to have occurred in the United States, and there is no known threat of any nerve agent use in the United States. This guide is a supplement to the FGA Safety Awareness for First On-Scene Responders document. Please visit httpschemm.nlm.nih.govnerveagentsFGA.htm for FGA-related resources. This guide is based on 1 the interpretation of available data on FGAs by U.S. government experts 2 previously developed federal guidance related to nerve agents and 3 feedback from local and state emergency responders. This guide encompasses a range of potential scenarios involving various methods of FGA dissemination and routes of exposure.

Subject Categories:

  • Chemical, Biological and Radiological Warfare
  • Protective Equipment
  • Weapons Effects (Biological)

Distribution Statement:

[A, Approved For Public Release]