11.1 STIR: Multi-level Hidden Markov Model for Co-translational Protein Targeting
Technical Report,25 May 2016,29 Apr 2017
Harvard University Cambridge United States
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The primary research goal of the project is to build mathematical models to investigate the unsolved questions regarding the molecular mechanism of the co-translational protein targeting process. The specific objectives are as follows. a Build a novel multi-level hidden Markov model for the conformational dynamics of the molecular complexes that govern the protein targeting process. This multi-level mathematical modeling allows to combine and extract information from multiple proteins for a deeper understanding of the molecular mechanism. bEmploy the multi-level hidden Markov model to account for the stochastic heterogeneity among the multiple proteins, which is necessary for detailed molecular understanding of the co-translational protein targeting process. c Apply the multi-level hidden Markov model to recent single-molecule experimental data on bacterial protein targeting systems. Direct fitting to the biological data not only gives the experimental assessment of the model, but also allows to extract experimental information in combination with our mathematical model to elucidate thedetailed molecular mechanism of protein targeting.
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