Effect of Hypobaria After Polytrauma on Gut Function and Its Microbiota
Technical Report,01 Mar 2016,30 Nov 2017
USAFSAM/FHE Wright-Patterson United States
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In the current study, we hypothesized that hypobaria would worsen polytrauma-induced gut dysfunction and lead to pathologic alterations in the gut microbiota. This was tested in an established model of controlled cortical impact-induced traumatic brain injury and hemorrhagic shock. We found that gut inflammation and injury were most significantly worsened in animals exposed to hypobaria at 100 acutely but also at 30 days after hypobaria and polytrauma. Changes in gut pathology were accompanied by changes in the gut microbiota, again most marked in the hypobaria 100 group at 30 days, with an increase in diversity and a significant increase in abundance of Bacteroides. Metatranscriptome data suggested that this technique might be able to detect changes early after polytrauma and hypobaria and warrants investigation in future studies.
- Medicine and Medical Research
- Anatomy and Physiology