Accession Number:

AD1065273

Title:

The Effect Of Vitamin D Supplementation On Bone Health Among Oncology Patients

Descriptive Note:

Technical Report

Corporate Author:

NAVAL POSTGRADUATE SCHOOL MONTEREY CA MONTEREY United States

Personal Author(s):

Report Date:

2018-09-01

Pagination or Media Count:

89.0

Abstract:

We performed a meta-analysis of all published data regarding the possible benefits of vitamin D andor calcium supplementation for increasing bone mineral density BMD in cancer patients. Currently, there is no medical community consensus as to whether vitamin D andor calcium affects bone health among cancer patients enough to offset the effects of chemotherapy. The Department of Defenses drug formulary, managed by the Pharmaceuticals and Therapeutics P and T committee, states that insurance does not cover multivitaminmultimineral supplements. The lack of coverage and consensus leaves patients in the dark about a potential benefit to a treatable disease. Therefore, we assessed the known research to offer more clarity to the committee. The thesis weighs evidence with a pooled effect, or weighted average, known as meta-analysis, and assessed risk of bias and quality of evidence via GRADE pro software. Of over 700 possible studies, 14 met our inclusion criteria, including four randomized control trial RCT and 10 observational studies. One RCT with an outcome on 25OHD levels and three observational studies found significant evidence of supplementations benefits, while the rest showed no significant findings. While overall we determined there was no significant benefit, we offer a solid base of understanding to the committee and recommend further research.

Subject Categories:

  • Anatomy and Physiology
  • Biochemistry
  • Food, Food Service and Nutrition
  • Anatomy and Physiology
  • Biochemistry
  • Food, Food Service and Nutrition

Distribution Statement:

APPROVED FOR PUBLIC RELEASE