A Pilot Study of Molecular Neuroimaging of Cerebral Blood Flow Abnormalities due to Traumatic Brain Injury (TBI) in a Swine Model (Sus scrofa)
Technical Report,17 Dec 2015,13 Dec 2018
DAVID GRANT USAF MEDICAL CENTER TRAVIS AFB CA TRAVIS AFB United States
Pagination or Media Count:
Objective To determine whether there are changes in cerebral blood flow in the setting of acute traumatic brain injury. Materials and methods A dose of Tc-99m-HMPAO tracer was administered to one sus scrofa, without a controlled cortical impact CCI and this subject was imaged on SPECT-CT. A second dose of Tc-99mHMPAO tracer was administered in a subject with a CCI, which was then imaged with SPECT-CT. Results The subject without a CCI SPECT-CT demonstrated a normal CT appearance of the brain and symmetric blood flow. The subject with a CCI SPECT-CT demonstrated post-craniotomy changes and no structural changes i.e., no intracranial hemorrhage and asymmetrically decreased blood flow to the injured brain. Conclusions In this limited study, the traumatic brain injury was found to have decreased blood flow acutely, which can be imaged with SPECT-CT. This is consistent with the literature where decreased blood flow has been documented on CT Perfusion examinations. SPECT-CT represents a potential for improving diagnosis of blood flow changes in the setting of traumatic brain injury by capturing early blood flow changes post-TBI i.e., via early administration of the radiotracer shortly after the TBI or providing the potential to image certain patients who cannot have CT Perfusion e.g., allergy or MRI perfusion e.g., contraindication to MRI.