Evaluation of Hypotensive Resuscitation +/- Aeromedical Evacuation and the Effects of Oxygen Therapeutics During Prolonged Field Care in a Swine Polytrauma Model
Technical Report,01 Aug 2017,31 Jul 2018
Naval Medical Research Center Silver Spring United States
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In light of the potential for future conflicts in parts of the world where immediate evacuation of combat casualties might not be possible, research is needed to address knowledge gaps during prolonged field care and its effects on subsequent long range patient transport to definitive care. For example, there is no data available about the impact of prolonged hypotensive resuscitation on vital organ function in TBI and polytrauma patients. Novel resuscitation fluids that might provide efficient oxygenation to vital tissue beds in the PFC environment need to be assessed for efficacy, as they may improve pre-hospital care and subsequent outcome of combat casualties. The knowledge gained will be used to optimize care provided to our wounded service members as they are moved through the en route system. The proposed research will provide needed data on the impact of prolonged hypotensive resuscitation for 72 hours on neurotrauma and polytrauma casualties and identify possible safety risks associated with aero-medical evacuation of patients. It also assesses whether or not hypotensive resuscitation is actually the best modality compared with normotensive in this PFC scenario. This study will directly address improvement of combat casualty safety, morbidity and mortality.
- Medicine and Medical Research