Accession Number:

AD1064845

Title:

Noninvasive Optical Monitoring of Spinal Cord Hemodynamics and Oxygenation after Acute Spinal Cord Injury

Descriptive Note:

Technical Report,01 Sep 2017,31 Aug 2018

Corporate Author:

University of British Columbia Vancouver Canada

Personal Author(s):

Report Date:

2018-09-01

Pagination or Media Count:

39.0

Abstract:

Our objectives in Year 2 are fully addressed. Following a series of technical refinements and pilot studies. OXT5V1 NIRS sensor prototype and our Multi-Wavelength NIRS system were developed. This setup was required for monitoring spinal cord oxygenation, hemodynamics and cytochrome c oxidase CCO activity in our animal model of acute SCI Experiment 1. We successfully completed Experiment 1 as scheduled in year 2. Nine animals were studied and comparative statistical analysis was completed. Outcomes of Experiment 1 are prepared for publication in the Journal of Neurotrauma. We will also present our results at 2018 Neuroscience conference in San Diego and at 2019 SPIE Photonics West conference in San Francisco. Following completion of Experiment 1,we proceed by conducting the 3rd round of NIRS technology development to design and prototype miniaturized V2-NIRS sensor and modified NIRS system enabled for continuous long-term data collection. V2-NIRS sensor is being tested in a series of pilot animal studies. In year three we conduct Experiment 2 and will focus on refining the technology to engineer a clinical spinal cord NIRS sensor.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Medical Facilities, Equipment and Supplies

Distribution Statement:

APPROVED FOR PUBLIC RELEASE