Noninvasive Optical Monitoring of Spinal Cord Hemodynamics and Oxygenation after Acute Spinal Cord Injury
Technical Report,01 Sep 2017,31 Aug 2018
University of British Columbia Vancouver Canada
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Our objectives in Year 2 are fully addressed. Following a series of technical refinements and pilot studies. OXT5V1 NIRS sensor prototype and our Multi-Wavelength NIRS system were developed. This setup was required for monitoring spinal cord oxygenation, hemodynamics and cytochrome c oxidase CCO activity in our animal model of acute SCI Experiment 1. We successfully completed Experiment 1 as scheduled in year 2. Nine animals were studied and comparative statistical analysis was completed. Outcomes of Experiment 1 are prepared for publication in the Journal of Neurotrauma. We will also present our results at 2018 Neuroscience conference in San Diego and at 2019 SPIE Photonics West conference in San Francisco. Following completion of Experiment 1,we proceed by conducting the 3rd round of NIRS technology development to design and prototype miniaturized V2-NIRS sensor and modified NIRS system enabled for continuous long-term data collection. V2-NIRS sensor is being tested in a series of pilot animal studies. In year three we conduct Experiment 2 and will focus on refining the technology to engineer a clinical spinal cord NIRS sensor.
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