Accession Number:

AD1064759

Title:

Distributed Spatiotemporal Dynamics of Synthetic Gene Circuits

Descriptive Note:

Technical Report

Corporate Author:

University of California, Biocircuits Institute La Jolla

Personal Author(s):

Report Date:

2018-10-12

Pagination or Media Count:

13.0

Abstract:

In this project we developed a multi-scale computational approach for analysis of multi-cellular processes in large bacterial populations and design of distributed synthetic gene circuits. This approach integrates discrete agent simulations of single cells with PDE modeling of large-scale dynamics. We applied this framework to computational modeling of spatiotemporal dynamics of growing bacterial biofilms and the dynamics of multi-strain bacterial populations.

Subject Categories:

  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE