Arylimidamide Azole Combinations against Leishmaniasis
Technical Report,28 Aug 2017,27 Aug 2018
The Geneva Foundation Silver Spring United States
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In vitro IC50s were determined for seventeen newly synthesized compounds. Most compounds showed high therapeutic indexes by displaying strong in vitro efficacy against L. major and L. donovani parasites but low in vitro toxicity when tested in a macrophage cell line. During the fourth and last year of this grant no compounds were tested in the in vivo models of cutaneous leishmaniasis.
- Medicine and Medical Research