Investigating the Role of PCM1 and Mib1 in Regulating Ciliogenesis and in Prostate Cancer
Technical Report,15 Jul 2016,14 Jul 2018
New York University New York United States
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The purpose of this research is to reveal the relationship between assembly of the primary cilium and prostate cancer by investigating two centrosomal proteins, pericentriolar material 1 PCM1 and Mind bomb 1Mib1, and to test the possibility that these proteins can serve as robust prostate cancer biomarkers and, potentially, targets for drug discovery. The primary cilium serves as a cellular antenna, and this organelle inhibits cell proliferation. The loss of this key signaling organelle was reported in various cancers, including prostate cancer. Therefore, we hypothesize that the absence of a primary cilium can potentially trigger cell proliferation and prostate cancer development. Pericentiolar material 1 is essential for ciliogenesis, and the PCM1 gene is deleted in 15 of prostate cancers. Our results indicate that ablation of pericentriolar material 1 leads to aberrant expression of its interacting partner, Mind bomb 1, an enzyme that is a negative regulator of ciliogenesis.
- Medicine and Medical Research