Tumor Slice Culture: A New Avatar in Personalized Oncology
Technical Report,01 Sep 2017,31 Aug 2018
Institute for Systems Biology Seattle United States
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The goal of this research is to advance our ability to precisely tailor therapy for solid tumors based on an ex-vivo TSC platform as a novel avatar of personalized oncology. The age of genomic medicine has brought tremendous hope to cancer patients, but the way in which this information gets translated to a clinical decision represents a major knowledge gap facing the oncologist. We now know that tumors with the same genetic mutation can have highly variable responses to targeted therapy. The lack of a functional assay with a quick turnaround time is the Achilles heel of personalized oncology. The objective of this proposal is to establish a robust, efficient, reproducible platform to interrogate drug sensitivity and to correlate the results with clinical and molecular data.
- Medicine and Medical Research