Long-Term Followup of the Delayed Effects of Acute Radiation Exposure in Primates
Technical Report,30 Sep 2017,29 Sep 2018
Wake Forest School of Medicine Winston-Salem United States
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This program studies the mechanisms and consequences of delayed effects of acute radiation exposure DEARE in non-human primates NHP, with complementary mechanistic and therapeutic studies in mice. The program consists of 4 projects, focused on 1. Type 2 diabetes mellitus T2DM 2. Radiation-induced heart disease RIHD 3. Chronic immune impairment and 4. Genomics and transcriptomics. Major findings include peripheral microvascular and bioenergetic abnormalities in NHP with T2DM restrictive myocardial fibrosis in RIHD dose and age-dependent immune impairment and ongoing sequencing work which will inform us regarding the molecular pathogenesis of T2DM, RIHD, and immune impairment in the context of DEARE.
- Medicine and Medical Research