Accession Number:

AD1064640

Title:

Long-Term Followup of the Delayed Effects of Acute Radiation Exposure in Primates

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Wake Forest School of Medicine Winston-Salem United States

Personal Author(s):

• Cline,J. M.

Report Date:

2018-10-01

Pagination or Media Count:

105.0

Abstract:

This program studies the mechanisms and consequences of delayed effects of acute radiation exposure DEARE in non-human primates NHP, with complementary mechanistic and therapeutic studies in mice. The program consists of 4 projects, focused on 1. Type 2 diabetes mellitus T2DM 2. Radiation-induced heart disease RIHD 3. Chronic immune impairment and 4. Genomics and transcriptomics. Major findings include peripheral microvascular and bioenergetic abnormalities in NHP with T2DM restrictive myocardial fibrosis in RIHD dose and age-dependent immune impairment and ongoing sequencing work which will inform us regarding the molecular pathogenesis of T2DM, RIHD, and immune impairment in the context of DEARE.

Descriptors:

• RADIATION EFFECTS
• exposure (physiology)
• cardiovascular physiological phenomena
• glucose metabolism disorders
• x ray computed tomography
• heart
• diabetes mellitus
• chemical synthesis
• body weight
• blood
• stem cells
• genomics
• IMMUNE SYSTEM

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE