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A Novel Animal Model for Investigating the Neural Basis of Focal Dystonia

Descriptive Note:

[Technical Report, Annual Report]

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State University of New York

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The overall goal of the project was to develop an animal model of the focal dystonia benign essential blepharospasm. Consistent with the widely held view that dystonia results from an interaction between a predisposing condition and an environmental trigger, we proposed to use 7 Hz deep brain stimulation of the basal ganglia as the predisposing condition and dry eye as the environmental trigger. We hypothesized that the 7 Hz deep brain stimulation would exaggerate the blink adaptations to dry eye into spasms of lid closure characteristic of benign essential blepharospasm. This reporting year we demonstrated that sex differences exist in the blink adaptations to dry eye. We are determining if the sex of the rat is important in developing our animal model of blepharospasm.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]