Accession Number:

AD1064012

Title:

Brain Consequences of Spinal Cord Injury with and without Neuropathic Pain: Translating Animal Models of Neuroinflammation Onto Human Neural Networks and Back

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Boston Children's Hospital

Personal Author(s):

• Linnman, Nils C.
• Yang, Teng

Report Date:

2018-10-01

Pagination or Media Count:

111

Abstract:

This project aims to investigate the consequence of spinal cord injury with regards to alterations in brain network function and expression of activated microglia, both human patients and in an animal model. During year three we have continued our collection of PET-MR data on spinal cord injured subjects, completed the rodent spinal cord injury surgeries and imaging procedures. Human imaging data is of consistently high quality and is reliably collected, albeit with some concerns regarding patient recruitment being slower than anticipated. The animal behavioral and imaging data is of high quality, and histological analysis is ongoing in parallell with neuroimaging analysis.

Descriptors:

• health services
• medical personnel
• brain
• chemical synthesis
• chemistry
• cell physiological processes
• brain injuries
• stem cells
• proteins
• neurosciences
• peptide growth factors
• cellular structures
• pain
• biological factors
• cardiovascular system
• drug abuse
• neurons
• peripheral nervous system
• vaccines
• anticonvulsants

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]