Macrophage Responses to Epithelial Dysfunction Promote Lung Fibrosis in Aging
Technical Report,30 Sep 2017,29 Sep 2018
Northwestern University Chicago United States
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Aim 1 and 2 Using mouse models of lung injury, fibrosis and epithelial dysfunction, we have demonstrated that microenvironment is a key factor driving phenotype of profibrotic alveolar macrophages. We have shown that epithelial dysfunction promotes recruitment of monocyte-derived alveolar macrophages and leads to exaggerated pulmonary fibrosis.
- Medicine and Medical Research