Accession Number:

AD1064005

Title:

Macrophage Responses to Epithelial Dysfunction Promote Lung Fibrosis in Aging

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Northwestern University Chicago United States

Personal Author(s):

• Misharin, Alexander
• Budinger,Scott

Report Date:

2018-10-01

Pagination or Media Count:

18.0

Abstract:

Aim 1 and 2 Using mouse models of lung injury, fibrosis and epithelial dysfunction, we have demonstrated that microenvironment is a key factor driving phenotype of profibrotic alveolar macrophages. We have shown that epithelial dysfunction promotes recruitment of monocyte-derived alveolar macrophages and leads to exaggerated pulmonary fibrosis.

Descriptors:

• fibrosis
• biomedical research
• patient care
• dysfunction
• bone marrow
• monocytes
• systems biology
• wounds and injuries
• computational biology
• macrophages
• epithelial cells
• tissue donors
• lung diseases

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE