Study of Biomarkers and Acute Radiation Sickness (ARS) Prognosis/Outcome Factors after Mixed-Field (Neutron and Gamma) Radiation in a Mouse Total-body Irradiation Model for Use in an FDA Approved Point-of-Care Biodosimetry System
Technical Report,01 Jan 2016,31 Aug 2018
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD BETHESDA United States
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The detonation of a nuclear weapon or a nuclear accident represent possible mass-casualty events with significant exposure to mixed neutron and gamma radiation fields in the first few minutes after the event with the ensuing fallout extending for miles from the epicenter that would primarily consist of photon exposure. Circulating biomarkers represent a crucial source of information in a mass casualty radiation exposure triage scenario. Evaluated multiple blood bio dosimetry and organ-specific biomarkers for early-response assessment of radiation exposure using a mouse total-body irradiation model, exposed to pure photons over a broad dose range 3 to 12 Gy and dose rates of either 0.6 or 1.9 Gymin and compared the results with those obtained after exposure of mice with a mixed-field neutrons and photons using Armed Forces Radiobiology Research Institute Co-60 gamma source and Training, Research, Isotope, General Atomic Mark-F nuclear research reactor. The mixed-field studies were performed over a broad dose range 1.5 to 6 Gy, dose rates of either 0.6 or 1.9 Gymin, and using different proportions of neutrons and gammas. Efforts supplement the goal to deliver an FDA approved bio dosimetry device by expanding the use of its capability for a broader spectrum radiation exposure.