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Regulatory T Cell-Enriching Microparticles for Promoting Vascularized Composite Allotransplant Survival

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Technical Report,15 Sep 2017,14 Sep 2018

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University of Pittsburgh Pittsburgh United States

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The purpose of this work is to investigate the ability of engineered biomimetic drug delivery systems to prevent rejection and promote immunological tolerance in the context of composite tissue allotransplantation CTA. For this reporting period our goals were to fabricate and characterize microparticles to be used in animal surgeries, achieve IACUCACURO approval for animal work and start the first phase of rodent hind limb transplants. Particles containingIL-2,TGF, and rapamycin were fabricated and this triple cocktail, along with all pairwise iterations of the three components were tested for their ability to prevent hindlimb rejection via 2 subcutaneous injections. Data at present seems to suggest that the combination of all three factors yields the best results, however some groups are still in the follow up period and accordingly, no statistical significance can be claimed until the follow up period is completed this will happen within the next month.

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