Accession Number:

AD1062932

Title:

Cortical Photostiumlation Technology for Vision Prosthesis

Descriptive Note:

Technical Report,15 Apr 2017,14 Apr 2018

Corporate Author:

University of Maryland Baltimore United States

Personal Author(s):

• Kao,Joseph P.

Report Date:

2018-05-01

Pagination or Media Count:

13.0

Abstract:

The overall goal of the project is to evaluate the feasibility of using photochemical stimulation of cortical neurons as the basis for a visual prosthesis. Accomplishments during year 2 of the project include 1 production of oxNI-Glu, the caged glutamate compound, for in vivo toxicological and in vitro physiological studies 2 completion of toxicological studies showing that chronic infusion of oxNI-Glu into mouse cortex is benign and well-tolerated 3 in vitro photoactivation tests in mouse brain slices showing that focal photolysis of oxNI-Glu in situ can photoactivate cortical neurons reliably and 4 successful training of mice in an automated operant conditioning cage to exhibit conditioned behavior in response to a stimulus.

Descriptors:

• prostheses and implants
• glutamates
• neurons
• TOXICOLOGY
• photoactivation analysis
• photolysis
• brain
• neurotransmitters
• training
• visual perception

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE