Cortical Photostiumlation Technology for Vision Prosthesis
Technical Report,15 Apr 2017,14 Apr 2018
University of Maryland Baltimore United States
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The overall goal of the project is to evaluate the feasibility of using photochemical stimulation of cortical neurons as the basis for a visual prosthesis. Accomplishments during year 2 of the project include 1 production of oxNI-Glu, the caged glutamate compound, for in vivo toxicological and in vitro physiological studies 2 completion of toxicological studies showing that chronic infusion of oxNI-Glu into mouse cortex is benign and well-tolerated 3 in vitro photoactivation tests in mouse brain slices showing that focal photolysis of oxNI-Glu in situ can photoactivate cortical neurons reliably and 4 successful training of mice in an automated operant conditioning cage to exhibit conditioned behavior in response to a stimulus.
- Medicine and Medical Research
- Anatomy and Physiology