Accession Number:

AD1062931

Title:

Sigma-1 Receptor Agonists as a Novel Therapeutic for Brain Mitochondrial Dysfunction in Gulf War Syndrome

Descriptive Note:

Technical Report,01 Sep 2017,31 Aug 2018

Corporate Author:

Savannah State University Savannah United States

Personal Author(s):

Report Date:

2018-09-01

Pagination or Media Count:

11.0

Abstract:

Gulf War Syndrome or Illness GWI is a unique chronic health disorder with multiple symptoms including cognitive difficulties, fatigue, muscular pain, and gastrointestinal problems. GWI is believed to be associated with prolonged or excessive exposure to various pesticides and pyridostigmine bromide PB. This toxicant exposure causes disrupted mitochondrial function in neurons and thus cognitive difficulties in GWI. Treatments that target at restoring mitochondrial function in neurons and improving cognitive abilities in GWI veterans are needed. Sigma-1 receptor S1R agonists have the potential to restore mitochondrial function. This study will test therapeutic efficacy of selected S1R agonists for cognitive difficulties in an established GWI mouse model.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE