Accession Number:

AD1062928

Title:

Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss

Descriptive Note:

Technical Report,14 Sep 2017,15 Sep 2018

Corporate Author:

Oregon Health and Science University Portland United States

Personal Author(s):

• Nuttall,Alfred L

Report Date:

2018-10-01

Pagination or Media Count:

22.0

Abstract:

In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss NIHL.The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the innerear that leads to noise-induced hearing loss NIHL. The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear resulting from a single acute sound exposure.

Descriptors:

• hearing loss
• hearing disorders
• inhibition
• mitochondria
• inhibitors
• tissues
• ear
• exposure(general)
• noise(sound)
• organ of corti
• free radicals
• cell physiological processes
• molecules
• dysfunction
• membranes

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE