Accession Number:

AD1062529

Title:

Vagus Nerve Stimulation as a Treatment Strategy for Gulf War Illness

Descriptive Note:

Technical Report,30 Sep 2017,29 Sep 2018

Corporate Author:

Texas A and M Health Science Center College Station United States

Personal Author(s):

Report Date:

2018-10-01

Pagination or Media Count:

16.0

Abstract:

The purpose of this research is to determine if vagus nerve stimulation VNS will be an effective therapeutic strategy for Gulf War Illness GWI. GWI refers to a chronic complex of symptoms observed in afflicted personnel. GWI symptoms include cognitive impairments memory and concentration problems, headaches, migraines, widespread pain, fatigue, gastrointestinal and respiratory issues, as well as other unexplained abnormalities that do not fit into classical medical diagnostic criteria. There are extensive clinical and experimental data showing that VNS treatment exerts beneficial effects in many of the aforementioned symptom domains associated with GWI. We are in the process of testing the efficacy of VNS treatment on behavioral, cognitive, inflammatory, neuroinflammatory and neuroanatomical outcome measures. We have had our manuscript on altered nociceptive sensitivity accepted for publication. We have also demonstrated changes in hippocampal astrocytes, hippocampal neurogenesis, and changes to cognitive function that rely on intact hippocampal neurogenesis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE