Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury
Technical Report,01 Aug 2017,31 Jul 2018
Wayne State University Detroit United States
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This proposal aims to investigate potential therapeutic approaches for sleep-disordered breathing SDB in patients with chronic cervical spine injury 6 months post-injury. Our central hypothesis is that cervical SCI is associated with frequent episodes of hypoxia, resulting in chronic intermittent hypoxia CIH, recurrent arousals from sleep, and increased peripheral chemoreceptor activity. To test our central mechanistic hypothesis, we propose a series of experiments to investigate the following Specific Aims 1 To test the hypothesis that patients with cervical SCI will demonstrate greater magnitude of LTF following EH during sleep, compared to patients with thoracic SCI.
- Medicine and Medical Research