Accession Number:

AD1062513

Title:

Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury

Descriptive Note:

Technical Report,01 Aug 2017,31 Jul 2018

Corporate Author:

Wayne State University Detroit United States

Personal Author(s):

• Badar,M S
• Vaughan,Sarah

Report Date:

2018-08-01

Pagination or Media Count:

8.0

Abstract:

This proposal aims to investigate potential therapeutic approaches for sleep-disordered breathing SDB in patients with chronic cervical spine injury 6 months post-injury. Our central hypothesis is that cervical SCI is associated with frequent episodes of hypoxia, resulting in chronic intermittent hypoxia CIH, recurrent arousals from sleep, and increased peripheral chemoreceptor activity. To test our central mechanistic hypothesis, we propose a series of experiments to investigate the following Specific Aims 1 To test the hypothesis that patients with cervical SCI will demonstrate greater magnitude of LTF following EH during sleep, compared to patients with thoracic SCI.

Descriptors:

• spinal injuries
• peripheral nervous system
• clinical trials
• ventilation
• SLEEP DISORDERS
• hypoxia
• therapy
• serotonin agents
• air pressure
• chemoreceptors
• respiration

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE