Molecular Signature of Acute Rejection in Clinical Face Transplants
Technical Report,15 Jul 2017,14 Jul 2018
BRIGHAM AND WOMENS HOSPITAL BOSTON MA BOSTON United States
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Vascularized composite allotransplantation VCA, such as face and limb transplantation, is life transforming. Immunosuppression following VCA transplantation is based on protocols used in solid organ transplantation, but it is unclear if this is appropriate. The aims of this project are to i determine the molecular phenotype of human face transplant rejection, iicompare gene expression profiles of facial transplant rejection with that of inflammatory dermatoses, iii compare gene expression profiles of facial transplant rejection with publically available gene expression datasets in solid organ transplants. We hypothesize that there are unique as well as shared molecular features in face transplant rejection compared to solid organ transplant rejection. Determination of unique features of face transplant rejection will highlight the need for and facilitate the development of targeted therapies for VCA recipients.
- Medicine and Medical Research