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New Advanced Technology to Improve Prediction and Prevention of Type 1 Diabetes

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Technical Report,01 Nov 2006,31 Oct 2007

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Childrens Hospital of Pittsburgh Pittsburgh United States

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Type 1 diabetes is considered an autoimmune disease characterized by the presence of inflammatory cells in the islets of Langerhans. These cells are T lymphocytes, considered responsible for the destruction of the insulin producing beta-cells present in the islets. When the majority of the beta cells are dead, the disease presents, frequently with an abrupt and clinically serious onset. The aim of this program is to determine whom among the Army personnel is at high risk to develop the disease in order to prevent the unexpected onset of the disease that may be associated with tragic consequences, and to initiate an educational program aimed at reducing practical and psychological hurdles. Furthermore, different individuals develop disease complications i.e., retinopathy, nephropathy, neuropathy at different time-points after the onset. The susceptibility to complications could also be genetic. The human genome will be scanned systematically to characterize these susceptibility genes. Proteomic analysis will be performed in tandem to confirm the genetic associations.

Subject Categories:

  • Medicine and Medical Research

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