Intra-Articular Lubricin Gene Therapy for Post-Traumatic Arthritis
Technical Report,15 Aug 2017,14 Aug 2018
University of Iowa Iowa City United States
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This project focuses on addressing cartilage lubricant failure in post-traumatic osteoarthritis PTOA via intra-articular lubricinproteoglycan 4 PRG4 gene therapy. Our findings thus far indicate that a single intra-articular injection of adeno-associated virus AAV bearing the PRG4 gene in a rabbit ACL transection ACLT model resulted in transgene expression until the end-point of the experiment at 8 weeks post-op, and that the injection treatment was chondroprotective. PRG4 gene therapy appears to be a viable option for slowing the progression of PTOA, a finding that warrants investigation of the strategy in a large animal model. Accordingly we applied for a PRMRP Focused Program Award FPA,which includes a project to pursue lubricin gene therapy in a Yucatan Minipig intra-articular fracture model. The proposal was recently.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research