Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System
Technical Report,01 Sep 2017,31 Aug 2018
Van Andel Research Institute Grand Rapids United States
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We are interested in determining whether ambient air pollutants impact the development of Parkinsons disease PD by increasing -synuclein pathology via inflammation. In this aim we injected -synuclein -syn pre-formed fibrils PFF in the right olfactory bulbs of mice to model PD then exposed them to nano-particulate matter nPM for four weeks after injections. Ten weeks later, we euthanized the mice. We first confirmed that PFF injections induced the expected phosphorylated -syn pathology throughout olfactory areas, and we are presently determining whether nPM exposure worsened that pathology via neuroinflammation. In summary, we observe increased phosphorylated -syn pathology in the cortical amygdala after nPM exposure.
- Medicine and Medical Research