Accession Number:

AD1061918

Title:

Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Descriptive Note:

Technical Report,01 Sep 2017,31 Aug 2018

Corporate Author:

Van Andel Research Institute Grand Rapids United States

Personal Author(s):

Report Date:

2018-09-01

Pagination or Media Count:

13.0

Abstract:

We are interested in determining whether ambient air pollutants impact the development of Parkinsons disease PD by increasing -synuclein pathology via inflammation. In this aim we injected -synuclein -syn pre-formed fibrils PFF in the right olfactory bulbs of mice to model PD then exposed them to nano-particulate matter nPM for four weeks after injections. Ten weeks later, we euthanized the mice. We first confirmed that PFF injections induced the expected phosphorylated -syn pathology throughout olfactory areas, and we are presently determining whether nPM exposure worsened that pathology via neuroinflammation. In summary, we observe increased phosphorylated -syn pathology in the cortical amygdala after nPM exposure.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE