Evaluating the Metabolic Changes Associated with Exercise in Multiple Sclerosis
Technical Report,01 Aug 2017,31 Jul 2018
John Hopkins University Baltimore United States
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Currently available pharmacological therapies do not improve MS symptoms, such as weakness. Exercise training improvesmultiple symptoms associated with MS, including weakness, fatigue and mood disturbance. Exercise produces alterations inmultiple metabolic pathways and some of these changes may underlie the beneficial effects of exercise. We hypothesized thatmetabolic alterations produced by strength training will predict symptomatic changes in people with MS. In this study we areenrolling adults with MS N20 and age- and gender-matched healthy controls N20. Participants undergo 12-weeks ofguided Progressive Resistance Training 3-times weekly. At baseline and end-of-study we collect measures of fatigue, strength,physical fitness, cognition and overall impairment, in addition to blood for metabolomics. At the end of the study plasmasamples will undergo global untargeted metabolomics analysis to identify metabolites and determine their concentrations. Wewill then perform analyses to identify metabolites that are altered with exercise and also identify metabolites that are related tochanges in MS symptom severity. This study has the potential to identify the mechanisms by which exercise impacts the metabolome in MS patients. Identification of metabolic pathways that are associated with symptomatic benefits could lead to the development of alternative treatment strategies, both pharmacologic and neuro-rehabilitative, for targeting these pathways.
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