Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System
Technical Report,01 Sep 2017,31 Aug 2018
University of Southern California Los Angeles United States
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We are interested in determining whether ambient air pollutants impact the development of Parkinsons disease PD by increasing -synuclein pathology via inflammation. In this aim we injected alpha -synuclein alpha-syn pre-formed fibrils PFF in the right olfactory bulbs of mice to model PD then exposed them to nano-particulate matter nPM for four weeks after injections. Ten weeks later, we euthanized the mice. The Brundin lab confirmed that PFF injections induced the expected phosphorylated -syn pathology throughout olfactory areas. nPM exposure increased phosphorylated -syn pathology only in the cortical amygdala. Importantly, we determined that nPM exposure did not show the expected increase of inflammatory or oxidative markers suggesting that these nPM effects may have been resolved during this extended period of time 10 weeks when mice were not exposed to nPM.
- Medicine and Medical Research
- Air Pollution and Control