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Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy

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Technical Report,01 Jul 2017,30 Jun 2018

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University of California, Los Angeles Los Angeles United States

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During the second funding period we partially fulfilled Major Task 3. The degree of lymphocyte infiltration was assessed in premalignant n 328 and malignant lesions n 15AIS and 50 ADC, along with adjacent histologically normal areas n 50 in lobectomy specimens from 41 patients who had undergone surgery for early stage ADC. Lymphocyte infiltration was graded 0-to-3 based on H and E staining and was significantly increased in AAHvs. normal areas and became highest in AIS and ADC. Expression of regulators of cell-mediated immunity, including CD4, CD8, FOXP3, PD-1 and PD-L1 was quantified in AAH and ADC in a subset of 9 cases by immunohistochemistry. Quantitative multiplex immunofluorescent staining for 8immune markers in the entire study cohort 41 cases is ongoing and will be completed during the No Cost Time Extension.

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  • Medicine and Medical Research

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