Accession Number:

AD1061765

Title:

Molecular and Cellular Determinants of Malignant Transformation in Pulmonary Premalignancy

Descriptive Note:

Technical Report,01 Jul 2017,30 Jun 2018

Corporate Author:

University of California, Los Angeles Los Angeles United States

Personal Author(s):

Report Date:

2018-07-01

Pagination or Media Count:

9.0

Abstract:

During the second funding period we partially fulfilled Major Task 3. The degree of lymphocyte infiltration was assessed in premalignant n 328 and malignant lesions n 15AIS and 50 ADC, along with adjacent histologically normal areas n 50 in lobectomy specimens from 41 patients who had undergone surgery for early stage ADC. Lymphocyte infiltration was graded 0-to-3 based on H and E staining and was significantly increased in AAHvs. normal areas and became highest in AIS and ADC. Expression of regulators of cell-mediated immunity, including CD4, CD8, FOXP3, PD-1 and PD-L1 was quantified in AAH and ADC in a subset of 9 cases by immunohistochemistry. Quantitative multiplex immunofluorescent staining for 8immune markers in the entire study cohort 41 cases is ongoing and will be completed during the No Cost Time Extension.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE