Accession Number:

AD1061762

Title:

Drosophila as a Screening Platform for Novel Lung Cancer Therapeutics

Descriptive Note:

Technical Report,01 Sep 2015,31 Aug 2017

Corporate Author:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI NEW YORK NEW YORK United States

Personal Author(s):

Report Date:

2017-11-01

Pagination or Media Count:

16.0

Abstract:

The research in this grant is designed to explore the effects of genetic and genomic complexity in lung cancer progression and response to therapeutics. Using Drosophila, we are establishing a set of personalized fly lines, each which represents a separate patient. In this Progress Report, I discuss our initial studies in building these lines. In addition, I discuss our results with screening a library of 1200 FDA approved drugs. We provide evidence that a two drug cocktail, trametinib plus fluvastatin, synergize to improve efficacy and minimize toxicity in fly and human cell line models.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE