Expression of Mobility Group Box 1 Protein in a Polytrauma Model Treated with ECLS at Ground Level and High Altitude
59 MDW San Antonio United States
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Acute respiratory distress syndrome ARDS is the most severe form of acute lung injury, characterized by acute onset of hypoxemia, bilateral radiographic pulmonary infiltrates without cardiogenic pulmonary edema, and may lead to sepsis and multi-organ failure. Injuries incurred in austere environments, particularly in the combat setting, require immediate evacuation with en-route critical care support. Extra corporeal membrane oxygenation ECMO may be used to support ARDS patients during transport, including during aeromedical evacuation. High mobility group protein box 1 HMGB1 is an important indicator of damage-associated molecular pattern DAMP expression and disease progression in ARDS. HMGB1 has been identified as a mediator of ARDS and is expressed in blood following activation of damaged cells. Little is known regarding HMGB1 expression in a pulmonary contusion model of ARDS supported by ECLS at ground level. Altitude change effect on HMGB1 expression during air transportation is also unknown.
- Medicine and Medical Research