Nanoelectronics Innervated Cells, Cell Networks and Three-Dimensional Biomaterials
Technical Report,15 Jun 2014,04 Sep 2018
HARVARD UNIV CAMBRIDGE MA CAMBRIDGE
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The overall objective of this research is to develop nanoelectronic devices and macroporous mesh nanoelectronic networks for hybrid nanoelectroniccell and cell network three-dimensional 3D biomaterials. To this end, we developed an ultra-flexible syringe-injectable mesh nanoelectronics framework that can interface to biosystems with minimal chronic immune response, a novel multifunctional bioelectronic probe that can simultaneously record biomechanical and bioelectrical processes from the same cell, and free-standing nanoelectronic probes that can achieve highly localized electric field-based stimulation of primary neuronal cells. We have further developed this new paradigm of ultra-flexible syringe-injectable mesh electronics with the goal of exploiting the capabilities of targeting and recording from specific cell types or neuron subtypes. The natural distribution of both neurons and glial cells achieved post-implantation with tissue-like mesh electronics reported in Year 1 suggests that functionalization of recording andor stimulation devices with antibodies or aptamers capable of recognizing and targeting specific cell surface receptors could enable in-vivo neuron subtype electrophysiology.
- Biomedical Instrumentation and Bioengineering
- Electrical and Electronic Equipment
- Anatomy and Physiology