Cyborgcell: Molecular Nanoscale Circuits for Active Control of Cells
Technical Report,15 Sep 2015,14 Sep 2018
Harvard College President and Fellows Cambridge United States
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The goal of this work is to develop molecular-nanoscale circuits that control cells via external radiation. We developed silicon nanowire probes as platform elements of these circuits and demonstrated their insertion into single cells followed by stimulation to elicit cell signaling, finally achieving a scalable, modular nanodevice platform capable of recording high-amplitude intracellular electrical signals in electrogenic cells. In parallel we developed a conformal deposition technique and site-selective deposition of polymers to modify probes, and an approach to decorate nanowires with heavy-metal-free quantum dot emitters that provide a strong, macroscopically addressable and reproducible nanoprobe emission signal.
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