The Molecular and Electrophysiologic Response to Chronic Intraneural Silicone Electrode Implantation
Technical Report,16 May 2016,15 Feb 2017
Nerves Incorporated Dallas United States
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Tissue inflammation due to chronic electrode implants has been reported as a dominant failure mechanism in most neural interfaces preventing acquisition of long term reliable neural information. The tissue reaction is thought to result from initial injury caused by the trauma of electrode implantation, as well as delayed damage due to chronic presence of electrode arrays. Evaluation of the foreign body response to neural interfaces have typically been limited to quantification of a small set of molecules. Thus, molecular components and pathways crucial for the tissue response specific to implanted neural interfaces remain largely unknown, especially in the peripheral nervous system. In this study we use whole genome microarrays to understand local gene expression changes in response to silicone longitudinal intrafascicular multi electrode arrays LIFEs in rat sciatic nerve. In addition to the cellular and molecular response, we characterize neural signaling quality and histological changes to chronically implanted LIFEs. Understanding the changes induced by the chronic presence of implanted electrodes at the molecular level will speed development of neural prosthetic devices used to restore function in cases of paralysis, amputation, and degenerative disease.
- Medicine and Medical Research
- Anatomy and Physiology
- Genetic Engineering and Molecular Biology