Causal Analysis of Rule-Based Models of Signalling Pathways
Harvard Medical School Boston, United States
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When a cell receives a signal from its environment through a membrane receptor, a cascade of internal reactions is triggered which leads ultimately to its response, usually a change in its metabolism, its ability to divide, or in the expression level of a gene. Many diseases including some forms of cancer are related to some defects in these signalling pathways. Such biological systems usually feature thousands of proteins interacting in a highly concurrent way and their complexity makes modelling necessary to the development of better biocuration techniques.
- Numerical Mathematics