Accession Number:

AD1058532

Title:

Causal Analysis of Rule-Based Models of Signalling Pathways

Descriptive Note:

Technical Report

Corporate Author:

Harvard Medical School Boston, United States

Personal Author(s):

• Laurent,Jonathan

Report Date:

2017-08-24

Pagination or Media Count:

42.0

Abstract:

When a cell receives a signal from its environment through a membrane receptor, a cascade of internal reactions is triggered which leads ultimately to its response, usually a change in its metabolism, its ability to divide, or in the expression level of a gene. Many diseases including some forms of cancer are related to some defects in these signalling pathways. Such biological systems usually feature thousands of proteins interacting in a highly concurrent way and their complexity makes modelling necessary to the development of better biocuration techniques.

Descriptors:

• models
• interactions
• proteins
• theorems
• ALGEBRA

Subject Categories:

• Numerical Mathematics
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE