The Role of Mesothelial Omentin in Ovarian Cancer Progression
Technical Report,01 May 2017,30 Apr 2018
University of South Florida Tampa United States
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We hypothesize that omentin ITLN1 suppresses ovarian cancer progression by sequestering lactoferrin from its receptor on the ovarian cancer cells and adipocytes, and that lactoferrin promotes ovarian cancer cells motility and growth. A majority of experiments proposed under Major goal 1 and 5, and subsets experiments proposed in Major goal 2, 6 have been accomplished. Our results demonstrated that lactoferrin triggers intracellular Caexp 2 mobilization, enhances the amplitude of cellular traction exerted on substratum, and increases expression of matrix metalloproteinase-1 MMP1 in ovarian cancer cells. We also showed that omentin could counteract the stimulating effects of lactoferrin on ovarian cancer cells. For Major goal 8, we have been successful to boost the circulating omentin levels in C57BL6 mice using adeno-associated virus.
- Medicine and Medical Research