Commentary: What Is the Link between Stringent Response, Endoribonuclease Encoding Type II Toxin-Antitoxin Systems and Persistence
Journal Article - Open Access
Universit Libre de Bruxelles (ULB) Gosselies Belgium
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In a recent paper published in Frontiers in Microbiology, Ramisetty et al. 2016 questioned the mainstream model regarding bacterial persistence proposed by the group of K. Gerdes Maisonneuve et al., 2011, 2013. Persistence is an important phenomenon thought to contribute to infectious diseases chronicity and antibiotic resistance selection Michiels et al., 2016. This reversible and low frequency phenotypic switch allows bacteria to enter a particular physiological state in which they can sustain the presence of a given antibiotic Kaldalu et al., 2016Wood, 2016.