Accession Number:

AD1057500

Title:

Zika Virus Persistence in Immune-Priviledged Organs

Descriptive Note:

Technical Report,15 May 2017,14 May 2018

Corporate Author:

Washington University St. Louis United States

Personal Author(s):

Report Date:

2018-06-01

Pagination or Media Count:

9.0

Abstract:

This project involves the study of Zika virus ZIKV persistence within immune privileged organs including the testes and eyes. We set out to understand the role of adaptive immunity e.g., B cells and T cells as well as interferon regulatory factors IRF3, IRF5, and IRF7 in controlling ZIKV persistence within immune-privileged organs. During this research period, we discovered that absence of humoral and cellular immune responses results in increased persistence of ZIKV in these organs. Additionally, our initial experiments indicate that interferon regulatory factors, and especially IRF7, also prevents ZIKV persistence in the eye and testes.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE