Synthetic Lethal Metabolic Targeting of Senescent Cells after Androgen Deprivation Therapy
Technical Report,01 Jul 2017,30 Jun 2018
University of Wisconsin System Madison United States
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Progression to castrate resistant prostate cancer for men with advanced prostate cancer PC results after the initiation of androgen deprivation therapy ADT. One underutilized therapeutic strategy that has the potential to dramatically improve outcomes is eradicating the persistent cancer cells that remain after ADT and likely play a key role in the development of castration-resistant PC. The initiation of ADT induces susceptibilities in PC cells that make them amenable to synergistic treatment and improved cell killing.
- Medicine and Medical Research