Prevention of Breast Cancer Skeletal Metastases with Parathyroid Hormone
Technical Report,01 Feb 2017,31 Jan 2018
The Leland Stanford Junior University Stanford United States
Pagination or Media Count:
During this research period we have demonstrated that parathyroid hormone PTH started at the same time as intramammary implantation of murine 4T1-BGL breast cancer cells can decrease metastases to the skeleton but not to lung, liver or spleen. We have further demonstrated that 4 weeks of pretreatment with PTH can decrease engraftment and growth of murine or human breast cancer cells injected into the in tratibial bone marrow cavity. PTH also decreases the migration of breast cancer cells towards osteoblasts in a Transwell assay. Some of the effects of PTH are mediated by decreasing expression of VCAM-1 in osteoblasts. Vcam1 mRNA andVCAM-1 protein are decreased in bones treated with PTH. Breast cancer cells engineered to overexpress VCAM-1 increase migration towards osteoblasts, and this is blunted by PTH treatment.
- Medicine and Medical Research