Accession Number:

AD1053734

Title:

Understanding the Interaction of Peptides and Proteins with Abiotic Surfaces: Towards Water Free Biologics

Descriptive Note:

Technical Report,04 Aug 2011,03 Nov 2017

Corporate Author:

University of Michigan - Ann Arbor Ann Arbor

Report Date:

2018-04-18

Pagination or Media Count:

38.0

Abstract:

The major goals presented in the original proposal Aim 1. Develop systematic understanding of abioticbiotic interfaces. We aim to understand, how the structure and activity of proteins and peptides immobilized on abiotic surfaces depends upon a the chemical and physical nature of the abiotic surface b the hysicochemical properties of the protein or peptide and c the nature of the surrounding medium water, air or other hydromimetic molecules. Aim 2. Develop design rules for water-free biologics based on engineered abioticbiotic interfaces. Using knowledge gained from studies in Aim 1, we aim to a engineer peptides and proteins with enhanced ability to retain structure and function in the absence of bulk water, and b develop abiotic surfaces displaying hydromimetic functionality that stabilizes the native structure and function of biological molecules in extremely low humidity or water-free interfaces i.e. a surface-air interface that lacks bulk water and in air that is not humidified.

Subject Categories:

  • Biochemistry
  • Physical Chemistry
  • Medicine and Medical Research
  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE