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Stress Hormone Enhancement of OP-induced Neuroinflammation as an Animal Model of GWI: The Role of Toll-like Receptors and Plasticity

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Technical Report,31 Oct 2016,30 Oct 2017

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Centers for Disease Control and Prevention Morgantown United States

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GWI is a multi-symptom disorder with features similar to sickness behavior e.g., fatigue, depression, cognitive impairments, sleep disturbances, gastrointestinal problems. The exposures and conditions in theater that caused GWI remain unknown but several classes of chemicals and physiologicalenvironmental conditions have been implicated. We are working to expand upon our previously developed mouse model of GWI combining corticosterone CORT, as a stressor mimic, and DFP, a sarin surrogate. As such, we have tested the combination of chlorpyrifos oxon CPO with CORT in our long-term exposure paradigm. However, using the lower dose of CPO being employed in the behavioral experiments did not result in significant neuroinflammation. Additionally, dose response studies are being performed to determine an appropriate dose for dichlorvos that produces neuroinflammation. In year 2, the CORT CPO regimen will be repeated with a higher dose of CPO and dichlorvos will be implemented in the GWI model.

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  • Medicine and Medical Research

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