Accession Number:

AD1052104

Title:

Developing Software for Pharmacodynamics and Bioassay Studies

Descriptive Note:

Technical Report,11 Sep 2017,10 Mar 2018

Corporate Author:

TCONNEX Inc. McLean United States

Personal Author(s):

Report Date:

2018-04-01

Pagination or Media Count:

31.0

Abstract:

The objective of the project is to develop a software system to process general pharmacologic, toxicological, or other biomedical research data that exhibit a non-monotonic dose-response relationship - for which the current parametric models fail. The software will analyze dose-response relationships using both monotonic and non-monotonic data. This will have significant effects on the prevention and treatment of injuries and diseases of soldiers and civilians. Military agencies, government agencies, and private sponsors will be benefited from new and improved approaches to analyze the general pharmacologic, toxicological, or other biomedical research data that exhibit a non-monotonic dose-response relationship for which the existing parametric models fail. We understand that the difference between monotonic and non-monotonic doses and responses can impact patient response and recovery. If existing and proposed methods for the study of the relationship between dose and response can be effectively implemented and compared, it will enable us to uncover important dose-response features e.g., drug resistance or virus mutation in response to viral infection or treatment evaluation based on experimentalclinical trial data.

Subject Categories:

  • Computer Programming and Software
  • Pharmacology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE